Since acetaminophen is often combined with other over-the-counter cold medications that contain fever-reducing ingredients, people may end up taking multiple doses and exceeding the daily limitations. ![]() To help navigate when to choose which of these common over-the-counter medications, Potter offers the following information about each pain and fever-reducer:Īcetaminophen (Tylenol’s generic name) is a popular option for treating cold and flu-like symptoms, but Potter cautions that users need to be aware of how much they take in a day. “However, there are some instances where one of these medicines may work better than its counterparts.” Potter, Ph.D., professor and chair of pharmaceutical sciences with the Texas A&M Health Science Center Irma Lerma Rangel College of Pharmacy. “All of these pharmaceuticals are useful to treat pain and reduce fever, which is why they’re such common occurrences in households,” said David E. Which one should you take? What are the differences to consider before taking? ![]() You open the cabinet, hoping to find something to help with the pain and discomfort, but find yourself faced with three choices: Advil, Aleve and Tylenol. Gastrointestinal adverse events occurred at higher rates in the statin and NAC groups, and patients in the modafinil group had more psychiatric adverse events than those in the placebo group.You wake up with a terrible headache, a sore muscle or yesterday’s sunburn is bothering you, and shuffle your way to your medicine cabinet. ![]() None of the other studies reported serious adverse events. One study reported an allergic reaction-rashes and itching-to fish oil and one reported four serious adverse events associated with NAC, though that study also reported five serious adverse events for placebo. Notably, neither sponsor type nor study quality affected the outcomes.ĭrilling down, the researchers identified that the greatest response came from NSAIDs, omega-3 fatty acids, statins, and minocyclines, although they noted that just three studies examined statins and minocyclines. Adjunctive therapy showed greater reduction in symptoms than the anti-inflammatories alone. Participants saw a benefit from both monotherapy with the anti-inflammatories and from adding them to existing antidepressant therapy, based on subgroup analysis. Overall, the anti-inflammatories proved 52% more effective in relieving symptoms and 79% more effective at banishing symptoms than placebo. The pooled analysis found that the anti-inflammatories significantly reduced depressive symptoms. The studies enrolled a total of 1,610 participants diagnosed with major depressive disorder. The anti-inflammatories included nonsteroidal anti-inflammatory drugs (NSAIDs), omega-3 fatty acids, cytokine inhibitors, statins, corticosteroids, minocycline, pioglitazone, modafinil, and N-acetyl cysteine (NAC). Twenty-six of the studies measured improvement on a depression scale. ![]() The meta-analysis pooled the data from 31 randomized clinical trials conducted through Januthat compared anti-inflammatories with placebo. A number of clinical trials have looked at the potential for anti-inflammatory therapy to ameliorate depression, with mixed results. Observational studies have found high levels of inflammatory markers such as interleukin-6, interleukin-2 receptor, C-reactive protein, and tumor necrosis factor-alpha in patients with depression and a reduction in markers associated with improvement in symptoms. The role of inflammation in depression and many other illnesses has been a hot topic for researchers in recent years. Others relapse and some stop the medications because of intolerable side effects or cost concerns. About 30% of patients with depression find no relief from prescription antidepressants or psychotherapy. So can other anti-inflammatories, such as statins and antibiotics.Ī simple, accessible, and inexpensive therapy could be good news for millions of people who suffer from depression. According to a study published October 28 in the Journal of Neurology Neurosurgery & Psychiatry, aspirin, ibuprofen, and fish oil can reduce the symptoms of major depression. Some of your customers could find relief from depression in the OTC and supplement aisles.
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